Sun Pharma’s GL0034 (Utreglutide), administered once weekly, demonstrated significant body weight reduction of up to 6.8% over 10 weeks and notable improvements in metabolic markers in individuals with obesity and metabolic dysfunction-associated steatohepatitis (MASLD). The treatment was well-tolerated, presenting a potential breakthrough in obesity therapy.
Sun Pharmaceutical Industries Limited has unveiled encouraging results from clinical studies evaluating GL0034 (Utreglutide), a once-weekly GLP-1 receptor agonist targeting obesity and MASLD. In a 10-week dosing regimen, participants experienced a clinically meaningful average body weight reduction of 6.8%. Extended data from a 13-week trial in obesity and MASLD patients also showed substantial improvements in liver fat, fibrosis markers, glucose metabolism, lipid profiles, and inflammation biomarkers.
These findings underscore GL0034’s potential not only to induce weight loss but also to improve associated cardio-metabolic health parameters, including reductions in HbA1c, triglycerides, total cholesterol, and non-HDL cholesterol. The studies reported favorable tolerability, with gastrointestinal side effects consistent with this drug class.
Sun Pharma’s lead investigator, Dr. Rajamannar Thennati, highlighted the compound’s novel ability to simultaneously address obesity and related metabolic liver disease, positioning GL0034 as a promising therapeutic advance warranting further large-scale clinical trials.
Key Highlights:
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Once-weekly Utreglutide dosing led to average 6.8% body weight loss in 10 weeks
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13-week treatment in MASLD patients showed marked liver fat and fibrosis improvement
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Significant reductions noted in HbA1c, glucose, lipids, and inflammatory markers
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Well tolerated with typical GLP-1 receptor agonist gastrointestinal effects
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Potential dual benefit for obesity and metabolic-associated steatohepatitis management
Source: Sun Pharma, Diabetes Journals, Medical Dialogues, Clinical Trials Arena