Sentynl Therapeutics, a Zydus Lifesciences subsidiary, has entered into an agreement with Korea’s PRG S&T to license Progerinin (SLC-D011), an investigational therapy for Hutchinson-Gilford Progeria Syndrome (HGPS). The deal strengthens Sentynl’s rare disease pipeline, with Phase 2A trial data expected in the first half of 2026.
Sentynl Therapeutics Inc., based in the U.S. and backed by Zydus Lifesciences, announced the licensing of Progerinin from PRG S&T. The molecule targets progerin, the abnormal protein driving accelerated aging in children with HGPS.
Clinical Development And Research Progress
Progerinin has orphan drug designation from the U.S. FDA and is currently in Phase 2A trials. Early preclinical studies in mouse models showed extended lifespan and improved health markers, offering hope for a new therapeutic option beyond the currently approved drug Zokinvy (lonafarnib).
Strategic Significance For Zydus And Sentynl
The acquisition underscores Zydus’ commitment to rare and ultra-rare diseases. Dr. Sharvil Patel, Managing Director of Zydus, emphasized the importance of advancing therapies for children with progeria, while Sentynl CEO Matt Heck highlighted the company’s dedication to translating scientific progress into real treatments.
Key Highlights
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Sentynl licenses Progerinin (SLC-D011) from PRG S&T
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Progerinin targets progerin protein in HGPS
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Phase 2A trial data expected by mid-2026
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Zokinvy remains the only approved HGPS therapy globally
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Progeria Research Foundation supports the program’s advancement
Sources: Zydus Lifesciences press release, Sentynl Therapeutics announcement