A new study published in Nature Communications shows that the human brain undergoes four major resets at ages 9, 32, 66, and 83. These shifts mark distinct phases in neural wiring, reshaping cognition, memory, and emotional processing, challenging the traditional idea of linear brain ageing.
Inside the announcement
According to Business Standard, News18, Frontline (The Hindu), and US News, neuroscientists at the University of Cambridge analyzed MRI diffusion scans of 3,802 individuals aged 0–90. The scans tracked how water molecules move through brain tissue, mapping neural connections. Researchers identified five broad epochs in brain development, divided by four pivotal turning points. These resets reflect structural reconfigurations that influence how we think, learn, and adapt across life stages.
Notable updates
• First reset at age 9 marks transition from childhood to adolescence, reshaping learning and social cognition
• Second reset at 32 reflects adult brain reorganization, linked to emotional regulation and decision-making
• Third reset at 66 highlights ageing-related changes in memory and processing speed
• Fourth reset at 83 shows late-life rewiring, impacting resilience and cognitive decline patterns
• Study underscores that brain ageing is non-linear, with distinct phases rather than steady decline
Major takeaway
The research reframes our understanding of brain development, showing that neural architecture evolves in stages throughout life. These turning points highlight opportunities for targeted interventions in education, mental health, and ageing support.
Sources: Business Standard, News18, Frontline (The Hindu), US News