Suven Life Sciences announced achieving 100% patient enrollment in its Phase-2b clinical trial of Ropanicant, a novel α4β2 nicotinic receptor antagonist for Major Depressive Disorder (MDD). Conducted across 35 U.S. sites, the trial targets 195 patients, with topline data expected mid-2026, signaling strong progress toward innovative CNS therapy.
Trial Milestone Achieved
Suven Life Sciences, a clinical-stage biopharmaceutical firm focused on CNS disorders, has reached full patient enrollment in its pivotal Phase-2b study of Ropanicant (SUVN-911). This randomized, double-blind, placebo-controlled trial evaluates the drug's efficacy and safety over six weeks, using the Montgomery-Åsberg Depression Rating Scale (MADRS) in MDD patients. Building on rapid prior progress—25% in two months, over 55% in three—the complete enrollment underscores high investigator and patient interest amid unmet needs in depression treatment.
Key Highlights
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Study Design: ~195 patients across 35 U.S. sites; compares Ropanicant doses to placebo for MDD symptom improvement.
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Timeline: Last Patient In anticipated by February 2026; topline results mid-2026 under FDA IND.
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Prior Success: Positive Phase-2a showed rapid onset, favorable safety; no major concerns in ongoing monitoring.
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Strategic Impact: Positions Ropanicant as potential novel MDD therapy via unique mechanism.
This milestone boosts Suven's pipeline momentum in CNS innovation.
Sources: Suven Life Sciences, Marketscreener, ClinicalTrials.gov, NSE India